Do you have any problems with the following:

Cardiovascular and Circulatory System

Circulatory complications, Thrombosis, High Blood Sugar, High Blood Pressure, Liver, Lethargy

Viral Related Ailments

Common Cold, Influenza, Dengue Fever, Hepatitis, Herpes (type 1 and 2, Type 8, Shingles, Chicken Pox)

Intestinal and Blood Parasites

Roundworms, Hookworms, Nematodes, Whipworms, Giardia, Tapeworms and Flukes, Malaria


Andrographis paniculata

  • Sambiloto is effective at removing and preventing intravenous blood clots & plaque. It is also a wonderful blood purifier, and Liver Cleanser.1, 2, 3
  • Sambiloto has been proven in research to inhibit viral growth, allowing the body's immune system to irradicate viral pathogens.1,
  • Sambiloto has been clinicly shown to assist in eliminating intestinal and blood parasites.

  • Please Scroll Below to read more information.


    Sambiloto - Andrographis paniculata


    Prolonged use of Sambiloto must be maintained in order to achieve the desired effect.
    Taking only 1 or 2 pills will not be effective.

    We do not make any official claims, and we are not held responsible for any adverse effects of your consumption of the supplements purchased from our company.

    Please Read the information below, as well as the external links to learn more information about Sambiloto.

    Please consult with your Doctor or Physician to see if these supplements are right for you.


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    The Interesting Properties of Sambiloto

    The links provided below are reputable independant scientific resources from: the U.S. National Library of Medicine, Biomedical Central, and National Center for Biotechnology Information.

    Read 760 research papers on Andrographis paniculata here.

    Read 1236 more research papers on Andrographis paniculata here.

    Read 95 more research papers on Andrographis paniculata here.

    Contact Us To Purchase Sambiloto bulk ground powder.


    Cardiovascular and Circulatory System Benefits

  • Cardioprotective: Sambiloto protects heart muscles.
  • Depurative: Sambiloto cleans and purifies the system, particularly the blood.
  • Anti-oxidant: Sambiloto operates against free radicals which limits Oxidative Stress in the blood stream.
  • Anti-hyperglycaemic: Sambiloto produced significant reduction in blood concentrations of sugar. Protective against diabetes.
  • Anti-Hypertensive: Sambiloto extract inhibited the increase in blood pressure that is caused by noradrenaline. Researchers believe that Sambiloto has this antihypertensive effect because it relaxes the smooth muscle in the walls of blood vessels. This relaxation prevents the blood vessel from constricting and limiting blood flow to the heart, brain, and other organs in the body. Sambiloto keeps blood, and therefore oxygen, flowing to the brain.
  • Thrombolytic: Blood clot eliminator (Clot-Buster), and other Cardiovascular Benefits, reduces chances of heart attack by reducing plaque (made up of calcium and fats) bulidup in arteries. Agents that dissolve the clots and increase blood flow through the blocked artery are constantly being sought. Sambiloto is being further researched to confirm its potential to be a part of the conventional medical treatment as an Antithrombotic.


    Anti-Cancer Benefits

  • Cancerolytic: Sambiloto is a potent stimulator of the immune system in two ways: (1) Antigen-specific response: antibodies are made to counteract invading microbes, and (2) Nonspecific immune response: macrophage cells scavenge and destroy invaders. Sambiloto activates both responses – making it effective against a variety of infectious and cancer-causing agents. It was the andrographolide component that was found to have the cancer cytotoxic ability. This ability to kill cancer cells was superior to the levels of the effectiveness recommended by the National Cancer Institute for a cytotoxic substance.
  • Source:



    Liver and Gall Bladder Benefits

  • Hepatoprotective: Very Effective protecting the liver and gall bladder by stimulating their functions excreting unnecessary waste and toxins, such as products of alcohol, paracetamol, acetaminophen toxicity.
  • Choleretic: alters the properties and increases the flow of bile.
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    Anti-Viral Benefits

  • Anti-viral: Supresses viral activity, and inhibits viral replication in diseases such as: Hepatitis, HIV, Dengue Fever, Herpes Simplex and Complex, Influenza, anything viral related.
  • Immune Enhancer: Increases white cell phagocytosis, inhibits HIV-1 replication, and improves CD4+ and T lymphocyte counts.


    Anti-Depressant Benefits

  • Sambiloto increases mental performance by promoting proper blood flow and oxygen to the brain reducing stress related depression. Diminished blood flow to the brain can cause short-term memory loss, ringing in the ears, dizziness, headaches, and impaired mental performance, which may be factors linked to some types of depression.
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    Anti-bacterial Benefits

  • The potential use of Sambiloto and its components are important especially because bacteria are showing resistance to drugs. Each time bacteria are exposed to an antibiotic, most are killed, but a few survive. These survivors go on to multiply and establish infections that cannot be treated with the original antibiotic, and in some cases there are no existing drugs to stop the bacteria. Although Sambiloto and other herbs are not substitutes for antibiotics, Sambiloto could have a complementary effect when used along with antibiotics helping to fight bacterial activity. Extracts of Sambiloto have been shown to have significant effects against the diarrhea associated with E. coli bacterial infections.
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    Respitory System Benefits

  • Expectorant: Promotes clearance of mucus from the respiratory system.
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  • Vermicidal: Kills intestinal worms.
  • Anti-filarial: Kills filaria (microscopic worms) that obstruct lymph channels in the body, leading to gross swelling termed elephantiasis.
  • Anti-malarial: Sambiloto has prophylactic properties which prevent infection and parasite multiplication in the blood stream. Two of the Andrographis paniculata components, neoandrographolide and deoxandrographolide, were found to be the most effective. Pretreating animals with neoandrographolide for fifteen to twenty-one days prior to exposure as well as after infection was found to be more effective than treatment started only after infection. Effects were better than treatment after infection with chloroquine, a commonly used antimalarial drug.
  • Read More:


    Sambiloto's Effect on Sexual Organs

  • Anti-fertility: Sambiloto has been shown to have anti-fertility effects. This includes abortionant properties. That is it can abort pregnancy. We recommend all women avoid its use during pregnancy as a precaution.
  • Antispermatogenic: (sperm production blocking) or antiandrogenic (blocking effects of sex hormones known as androgens). We recommend couples trying to concieve, to avoid its use.
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    Sambiloto's Effect on Other Diseases

  • Leptospirosis is a disease caused by the bacterium Leptospira interrogens. Infection with this organism results in fever, hemorrhagic (blood-containing) lesions, central nervous system dysfunction, and jaundice. Several studies have reported efficacy in approximately 80% of patients treated with deoxyandrographolide, andrographolide, and neoandrographolide tablets.
  • Acute pyelonephritis is an inflammation of the kidney, particularly due to local bacterial infection. In a study evaluating the effectiveness of Sambiloto in treating this disease, Sambiloto was compared with nitrofurantoin, a standard clinical drug for pyelonephritis therapy. Sambiloto was found to be just as effective as the standard drug, but with fewer side effects.
  • Additional diseases reported to be effectively treated by herbal combinations that include Sambiloto are: Japanese B encephalitis, cervical erosion, pelvic infection, otitis media purulence, cutaneous gangrene in infants, vaginitis, leprosy, herpes, chicken pox, and mumps, neurodermatitis, eczema, jaundice, gonorrhea, insecticidal, cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria.
  • When cobra venom was given to mice, Sambiloto prolonged survival time and postponed the occurrence of respiratory failure caused by the venom.
  • Extract and pure compounds of the plant have been reported for their anti-microbial, cytotoxicity, anti-pyretic, anti-protozoan, anti-inflammatory, anti-oxidant, immunostimulant, anti-diabetic, anti-infective, anti-angiogenic, hepato-renal protective, sex hormone/sexual function modulation, liver enzymes modulation, and toxicity activities.
  • Read More:


    Safety & Contraindications

    Sambiloto has long been perceived as safe. Although trial and error in humans may not be considered scientific, it is a way of determining whether a substance is effective or harmful. When scientists began to investigate the safety of Sambiloto, formal toxicological studies in animal models and in animal and human clinical trials confirmed that andrographolide and other members of this family of compounds have an extremely low toxicity. Rarely, people who use Sambiloto experience dizziness and heart palpitations. As with all herbs, some people will have an allergic reaction to Sambiloto. The other side effect, as discussed above, is antifertility. Overall, evidence to date indicates that andrographolides are naturally occurring compounds with low toxicity when used appropriately. The use of Sambiloto has been associated with allergic reactions ranging from minor skin rashes to more serious anaphylaxis, which is a potential problem at high doses when there is an allergic reaction. The obvious solution in these rare cases is to avoid its use.

    In almost every other respect Sambiloto has an extremely low toxicity.


    Chemical Properties

    Andrographis paniculata has various compounds in its aerial parts and roots and these are often used in extracting its active principles. Of the diterpenoids that have been identified and isolated from Andrographis paniculata, Andrographolide is the most prominent in occurrence and quantity. The leaves contain the highest amount of Andrographolide (2.39%), the most medicinally active phytochemical in the plant, while the seeds contain the lowest. Andrographolide has a very bitter taste, and it is colourless and crystalline in appearance. Dominant diterpenoids other than andrographolide which have been isolated mostly from the aerial parts of Andrographis paniculata include deoxyandrographolide and neoandrographolide. These diterpenoids have been isolated from the leaves. Other diterpenes besides the dominant ones have also been isolated from the leaves, among these is an unusual 23 carbon terpenoid isolated from the roots and aerial parts of the plant. Phytochemical studies of Andrographis paniculata has led to the isolation of various plant metabolites. Notable among these metabolites are the terpenoids (entalabdane diterpene lactones) which account for a large proportion of its components and therapeutic activity. Other categories of compounds that have also been isolated include flavonoids (flavones), noriridoides, xanthones, polyphenols and trace and macro elements.

    Read More:


    Known Mechanisms of Action

    Sambiloto (Andrographis paniculata) has been extensivly studied, most of it in the last half of the 20th century, and much of it concentrating on Sambiloto’s pharmacological composition, safety, efficacy, and mechanisms of action.
    A good deal of this research has centered around a screening technique called signal transduction technology – probably best explained in a seminal work by Jean Barilla, M.S.:

    ”One of the criticisms made by the conventional medical and scientific community regarding dietary supplements is that their development and use have been based on folklore, not science. Using signal transduction technology to investigate the effect on a botanical or other nutrition supplement on the cell-level processes of cells is good science. This approach will legitimize the nutritional approach to the prevention and treatment of disease and speed the process of development of new and more effective supplements."

    “Using signal transduction technology, extracts of Andrographis paniculata (Sambiloto) have been found to counteract interference with the cell cycle. Such interference is the basis for the development of cancer or infection with viruses such as HIV. Andrographolides are thought to enhance immune system functions such as production of white blood cells (scavengers of bacteria and other foreign matter), release of interferon, and activity of the lymph system. Interferon is a protein (called a cytokine) made by cells in response to viruses. It is a potent antiviral agent and is also antiproliferative (stops the reproduction of viruses)."

    The lymphatic system is an important part of the immune system. Briefly, it is another circulatory system (like the vascular system) that carries a fluid, the lymph. The lymph carries away the by-products of cellular metabolism and also acts as a shuttle for invading bacteria and viruses, taking them to the lymph nodes where the white blood cells (lymphocytes) destroy them. Sambiloto, a superb immune system enhancer, is even more effective when combined with immune stimulators, such as the herb Meniran.

    The theory behind the mechanism of operation also confirms that Andrographolides are also likely to be useful in conventional cancer therapy after suitable scientific confirmation.

    Several studies have looked at the disposition of andrographolide in various organs of the body. Biodistribution experiments have been done in experimental animals. Following injection of radioactively labeled andrographolide, this compound appears to be widely distributed in the body. High concentrations are noted in the central nervous system (brain and spinal cord) and other organs with high blood flow, including the colon, spleen, heart, lungs, and kidneys. Andrographolide appears to have a relatively short half-life of approximately two hours.

    The term “half-life” refers to the time when the concentration of the compound in the body is half of what it originally was when it entered the body. This is what is left after the compound has been metabolized (broken down), changed into other forms (called metabolites), and excreted by one of several routes (urine, feces, exhaled air, sweat, or other body excretions). Compounds with short half-lives need to be given often since they do not stay in the body for long. Andrographolides are excreted fairly rapidly from the body via the urine and gastrointestinal tract. In some studies, 80 percent of the administered dose of andrographolide is removed from the body within eight hours, with excretion rates of more than 90 percent of the compound within forty-eight hours. A regular dosage is needed for effectiveness.

    The wide tissue and organ distribution and the immune-stimulating and regulatory actions of Sambiloto make it an ideal candidate in the prevention and treatment of many diseases and conditions."


    Read 760 research papers on Andrographis paniculata here.

    Read 1236 more research papers on Andrographis paniculata here.

    Read 95 research papers on Andrographis paniculata here.

    Contact Us To Purchase our Sambiloto Capsules, or bulk leaf, and bulk ground powder.