Temulawak

Curcuma xanthorrhiza

The Interesting Properties of Temulawak

Read 87 research papers on Curcuma xanthorrhiza here.

Read 156 more research papers on Curcuma xanthorrhiza here.

Read 8 more research papers on Curcuma xanthorrhiza here.

Contact Us To Purchase our Temulawak Capsules, or bulk leaf, and bulk ground powder.

-------------------------------------------------------------

Overview

Temulawak is also known as Javanese Turmeric. The compounds extracted from Temuluwak are Xanthorrhizol, (which has extremely interesting properties, and is the most abundant), several Curcuminoids, and Borneol. Xanthorrhizol is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza. Curcuma xanthorrhiza has been well established to possess a variety of biological activities such as anticancer, antitumor, antimicrobial, anti-inflammatory, antioxidant, hypotriglyceridaemic, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, anticariogenic, hepatoprotective, estrogenic and anti-estrogenic effects. Curcuma xanthorrhiza is reported to be useful for hepatitis, liver complaints, diabetes, rheumatism, cancer, hypertension, and heart disorders. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics.

-------------------------------------------------------------

Antimicrobial Properties

Xanthorrhizol is considered active against a variety of pathogenic microorganisms. The Antimicrobial effects of Xanthorrhizol included: Antibacterial, Anticandidal, and Antifungal activities.

  • Antibacterial - Actinomyces viscosus, Porphyromona gingialis, Streptococcus mutans, Staphylococcus aureus, Mycobacterium tuberculosis, methicillin-resistant S. aureus, Escherichia coli, Propionibacterium acnes
  • Anticandidal - Candida albicans, Candida. glabrata, Candida guilliermondii and Candida parapsilosis
  • Antifungal - Malassezia species, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Fusarium oxysporum, Rhizopus oryzae, and Trichophyton mentagrophtes
  • Read More: https://www.ncbi.nlm.nih.gov/pubmed/16617064

    Read More: https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0029-1243135

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/10844172

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/16599995

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/17236167

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/29657431

    -------------------------------------------------------------

    Anti-inflammatory Benefits

    Xanthorrhizol, and the natural curcuminoids sodium curcuminate and tetrahydrocurcumin have been shown to be a potent anti-inflammatory at low doses. Curcumin inhibits the metabolism of arachidonic acid, activities of cyclooxygenase, lipoxygenase, cytokines (interleukins and tumor necrosis factor), nuclear factor-κB (NF-κB) and release of steroids. Curcumin stabilizes lysosomal membranes and causes uncoupling of oxidative phosphorylation. It also possesses strong oxygen radical scavenging activity, which confers anti-inflammatory properties.

    Read More: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257229/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/16273545

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/17234720

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/12086400

    Read More: https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-3-11

    -------------------------------------------------------------

    Antioxidant Benefits

    Most natural anti-oxidants can be classified into two types of compounds, namely phenolic, and β-diketone. Sesaminol isolated from Sesame belongs to the former, while n-triacontane-16,18-dione isolated from the leaf wax of Eucalyptus belongs to the latter. Curcumin is one of the few anti-oxidants that possess both, phenolic hydroxy, and β-diketone groups in one molecule. Its unique conjugated structure includes two phenols and an enol form of a β-diketone. Therefore, it may have a typical radical trapping ability and a chain-breaking anti-oxidant activity. Curcumin is a potent anti-oxidant whose action mechanism is still not well understood.

    Read More: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519093/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/16273545

    Read More: https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-3-11

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/8520105

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/30266519

    -------------------------------------------------------------

    Anti-Cancer and Anti-Tumor properties

    Anticancer properties of Xanthorrhizol

  • Breast cancer - Induced mitochondrial-mediated apoptosis against MDA-MB-231 (↑ caspase-3, -9, cytochrome c and ↓ PARP-1) and MCF-7 cell apoptosis (↑ p53, ↓ Bcl-2 and PARP-1); acted as partial estrogen antagonist against T47D cell line.
  • Colon cancer - Induced cell cycle arrest (G0/G1, G2/M phase and increased sub-G1 peaks); mitochondrial pathway apoptosis (↑ caspase-8, -9 and-3), tBID and ↓ Bcl-XL protein, cleavage of PARP; ↑ NAG-1 may inactivate Akt pathway and subsequently suppressed GSK3β and mTOR.
  • Cervical cancer - Induced p53 and Bax-dependent apoptosis, but not Bcl-2 and E6.
  • Liver cancer - Mitochondrial pathway apoptosis(↑ p53 ↓ Bcl-2 and Bcl-XL), but not Bax; caspase activation (caspase-3 and -9, not -7) involved tBid; cleavage of PARP and DFF45/ICAD proteins.
  • Skin cancer - Induced apoptosis in HM3KO cells; decreased tumor multiplicity and tumor incidence in DMBA-initiated mouse skin, suppressed ODC, COX-2 and iNOS expression through NF-kB (blocking IkBα degradation) and or Akt, inactivated ERK, p38, JNK and Akt.
  • Lung cancer - Downregulation of MMP and COX-2 in MAPK/ERK pathway (decreased COX-2, MMP-9 and phosphorylated ERK); attenuated expression of JNK and p38; counteracted the effect of Raf-1.
  • Tongue cancer - Induced cell cycle arrest in G0/G1 and S + G2/M phase; downregulated the protein expression of Bcl-2, but not Bax.
  • Oral cancer - Caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells; inhibited the tumors number in buccal pouches in hamsters treated with DMBA.
  • Esophageal cancer - Reduced p-Akt and cyclin D1 expression; increased caspase-3 expression.
  • Read More: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618344/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/17465228/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/22465013/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/17234720/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/16158967/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/15567173/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/22627996/

    Read More: https://www.ncbi.nlm.nih.gov/pubmed/19926935/

    Read More: https://www.gastrojournal.org/article/S0016-5085(10)63360-4/abstract

    -------------------------------------------------------------

    Antihyperglycemic Benefits

    Xanthorrhizol Reduced the levels of insulin, glucose, FFA, TG in serum. Xanthorrhizol Reduced the size of epididymal fat pad and adipocyte. Xanthorrhizol Decreased the production of TNF-α, IL-6, IL-1β and CRP in adipose tissue, liver and muscle.

    Read More: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094874/

    -------------------------------------------------------------

    Nephroprotective and Hepatoprotective Properties

    Curcuma xanthorrhiza has been used for centuries in traditional system of medicine to treat several diseases such as hepatitis, liver complaints, and diabetes. It has been consumed as food supplement and “jamu” as a remedy for hepatitis. Hence, Curcuma xanthorrhiza was further explored for its potential as a functional food for liver related diseases. As such, initiative was taken to evaluate the antioxidant and hepatoprotective potential of Curcuma xanthorrhiza rhizome.

    Read More: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122155/

    -------------------------------------------------------------

    Read 87 research papers on Curcuma xanthorrhiza here.

    Read 156 more research papers on Curcuma xanthorrhiza here.

    Read 8 more research papers on Curcuma xanthorrhiza here.

    Contact Us To Purchase our Temulawak Capsules, or bulk leaf, and bulk ground powder.